Anti-HLA Donor-Specific IgG Subclasses and C1q-binding Evolution in Posttransplant Monitoring
نویسندگان
چکیده
منابع مشابه
Clinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter?
UNLABELLED Anti-HLA donor-specific antibodies (DSA) identified by single antigen bead array (SAB) are questioned for their excess in sensitivity and lack of event prediction after transplantation. POPULATION AND METHODS We retrospectively evaluated specific types of preformed DSA (class I, class II or C1q-fixing) and their impact on graft survival. Kidney transplantations performed across neg...
متن کاملDonor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients.
Donor-specific anti–histocompatibility leukocyte antigen antibodies (DSAs) have a strong and frequently considered universally deleterious effect on allografts. Preformed or de novo DSAs activate complement, induce endothelial cell proliferation, and mediate antibody-dependent cellular cytotoxicity (ADCC), resulting in progressive declines in allograft function and loss.1–3More than 5000 renal ...
متن کاملNon-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft Survival.
C1q-binding ability may indicate the clinical relevance of de novo donor-specific anti-HLA antibodies (DSA). This study investigated the incidence and risk factors for the appearance of C1q-binding de novo DSA and their long-term impact. Using Luminex Single Antigen Flow Bead assays, 346 pretransplant nonsensitized kidney recipients were screened at 2 and 5 years after transplantation for de no...
متن کاملFailure to find C1q-binding material and anti-IgG antibodies in ankylosing spondylitis.
C1q-binding immune complexes (C1C), anti-IgG antibodies (anti-IgG Ab), and complement levels were investigated in the serum of 37 patients with ankylosing spondylitis (AS). In all these studies the mean levels observed in patients with AS were similar to those in 31 normal subjects. Moreover, no significative difference in either CIC or anti-IgG Ab levels was observed when the patients were cla...
متن کاملQuestioning the added value of Luminex single antigen beads to detect C1q binding donor HLA-specific antibodies.
Luminex single antigen bead (SAB) technology enables highly sensitive and rapid characterization of immunoglobulin G (IgG) human leukocyte antigen (HLA)-specific antibodies. It is widely used to determine antibody compatibility for renal transplantation and to aid the diagnosis of antibody-mediated rejection and response to therapy. HLA-specific antibodies may contribute to allograft rejection ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transplantation Direct
سال: 2018
ISSN: 2373-8731
DOI: 10.1097/txd.0000000000000823